As the global headquarters of HELLO Trust, the Hong Kong branch oversees the organisation's international operations while continuing to run local initiatives. Its primary focus is supporting ethnic minority children, elderly communities, and organising regular volunteering opportunities across Hong Kong. The Headquarters also works closely with branches across the Greater Bay Area to coordinate regional projects and organisational development.

The Shenzhen branch focuses on supporting autistic individuals and raising awareness of autism within the local community. It regularly organises community activities, educational programmes, and inclusion initiatives for autistic children and their families. Shenzhen is also home to InspireMe Festival, HELLO Trust's annual flagship event dedicated to autism awareness and youth leadership.

As HELLO Trust's first international branch, the Appi branch focuses on school-based fundraising events and community festivals. Funds raised support rural communities and children across Japan while providing students with valuable leadership and volunteering opportunities.

The Hengqin branch focuses on organising fundraising initiatives that support children with physical disabilities, intellectual disabilities, and autism. Members regularly host community events while promoting inclusion and supporting organisations that provide services for children with additional needs.

The Nanning branch focuses on supporting ethnic minority communities through community service and fundraising initiatives. In recent years, the branch has increasingly contributed to research projects, helping other HELLO Trust branches better understand how they can effectively support these communities.

The Shanghai branch operates through two dedicated divisions, allowing it to support multiple communities across the city. One division focuses on supporting elderly people in suburban communities through regular visits, companionship programmes, and community engagement activities. The other division is dedicated to supporting children with heart diseases by organising fundraising initiatives, hospital and community visits, and awareness campaigns.

The Beijing branch specialises in organising educational service trips to rural communities across China. These programmes allow younger students to better understand rural life while volunteering through educational activities that support local children and schools.

The Guangzhou branch supports children in rural schools and communities with limited access to educational resources. Through interactive lessons and volunteer-led programmes, members regularly provide free English education while encouraging confidence, communication, and curiosity among young learners.

The Macau branch frequently collaborates with the nearby Hengqin branch on joint fundraising initiatives and community projects. Its primary focus is supporting children with disabilities and autism through volunteer activities, fundraising campaigns, and partnerships with local organisations.

The Roorkee branch supports children in rural communities by providing educational programmes that emphasise creativity, communication, confidence-building, and personal development. The branch aims to empower students with skills that extend beyond the classroom.

The Seoul branch focuses on supporting elderly people, recognising the high relative poverty rate among senior citizens in South Korea. Its initiatives promote food security, mental wellbeing, community engagement, and physical care through volunteering and fundraising activities.

The Tainan branch focuses on supporting elderly people across the city, recognising Taiwan's rapidly ageing population and Tainan's rich history as the island's oldest city. Through regular community visits, companionship programmes, and volunteer initiatives, members aim to reduce social isolation, promote mental wellbeing, and build meaningful relationships with seniors who have contributed greatly to the city's development. The branch is committed to ensuring that these individuals continue to feel valued, connected, and supported within their community.

The Manila branch focuses on providing free and accessible educational opportunities for children with cancer and children living in rural communities. Through educational programmes and volunteer initiatives, the branch aims to reduce educational inequality while supporting children's personal growth and confidence.